Ventricular cardiotrophin-1 activation precedes BNP in experimental heart failure
| Autor: | John C. Burnett, Alessandro Cataliotti, Michihisa Jougasaki, Issei Tachibana, Hanna Leskinen, Andreas Luchner, Amy M. Larsen |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Cardiotrophin 1 Heart disease Physiology Heart Ventricles Blood Pressure Biochemistry Cellular and Molecular Neuroscience Dogs Endocrinology Internal medicine Natriuretic Peptide Brain Gene expression medicine Animals RNA Messenger cardiovascular diseases Northern blot Heart Failure Regulation of gene expression Messenger RNA business.industry medicine.disease Brain natriuretic peptide Enzyme Activation Disease Models Animal Heart failure cardiovascular system Cardiology Cytokines business human activities hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Peptides. 24:889-892 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/s0196-9781(03)00163-3 |
| Popis: | Both cardiotrophin-1 (CT-1) and B-type or brain natriuretic peptide (BNP) are activated by cardiomyocyte stretch, and gene expression of CT-1 and BNP are augmented in the heart in experimental and human congestive heart failure (CHF). The goal of this study was to define cardiac gene expression of CT-1 and BNP by Northern blot analysis in normal (n=5), early left ventricular dysfunction (ELVD, n=5) and overt CHF dogs (n=5), in which ventricular function is progressively decreased. CT-1 mRNA was detected in both atria and ventricles in normal dogs. Ventricular CT-1 mRNA production increased in ELVD, and it further increased in overt CHF. Ventricular BNP mRNA remained below or at the limit of detection in normal and ELVD models, and it markedly increased in overt CHF. This study reports differential regulation of gene expression of CT-1 and BNP in the heart during the progression of CHF, and demonstrates that ventricular CT-1 gene activation precedes ventricular BNP gene activation. |
| Databáze: | OpenAIRE |
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