Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome
| Autor: | Jesus-Mario Luevano, Meaghan Flagg, Brian C. Keller, David B. Gootenberg, Yap Boum, Cynthia L. Monaco, Jeffrey N. Martin, Herbert W. Virgin, Craig B. Wilen, David R. Bangsberg, Guoyan Zhao, Alexander Lankowski, Douglas S. Kwon, Mark J. Siedner, Peter W. Hunt, Megan T. Baldridge, Scott A. Handley, David Wang, Efrem S. Lim, Musie Ghebremichael, Jason M. Norman |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Cancer Research microbiome 2.1 Biological and endogenous factors 2.2 Factors relating to the physical environment Enteropathy Uganda Aetiology Immunodeficiency Phylogeny systemic inflammation virome Microbiota Gastrointestinal Microbiome HIV Enteropathy adenovirus Enterobacteriaceae Healthy Volunteers AIDS Infectious Diseases Anti-Retroviral Agents Medical Microbiology Viruses HIV/AIDS Infection Immunology 030106 microbiology Biology Microbiology Article 03 medical and health sciences Acquired immunodeficiency syndrome (AIDS) Clinical Research Immunology and Microbiology(all) Virology Genetics medicine Humans Human virome Microbiome Molecular Biology Acquired Immunodeficiency Syndrome Bacteria Human Genome HIV Genetic Variation AIDS enteropathy medicine.disease biology.organism_classification Good Health and Well Being 030104 developmental biology Parasitology Digestive Diseases |
| Zdroj: | Cell host & microbe, vol 19, iss 3 |
| ISSN: | 1934-6069 |
| Popis: | Human immunodeficiency virus (HIV) infection is associated with increased intestinal translocation of microbial products and enteropathy as well as alterations in gut bacterial communities. However, whether the enteric virome contributes to this infection and resulting immunodeficiency remains unknown. We characterized the enteric virome and bacterial microbiome in a cohort of Ugandan patients, including HIV-uninfected or HIV-infected subjects and those either treated with anti-retroviral therapy (ART) or untreated. Low peripheral CD4 T cell counts were associated with an expansion of enteric adenovirus sequences and this increase was independent of ART treatment. Additionally, the enteric bacterial microbiome of patients with lower CD4 T counts exhibited reduced phylogenetic diversity and richness with specific bacteria showing differential abundance, including increases in Enterobacteriaceae, which have been associated with inflammation. Thus, immunodeficiency in progressive HIV infection is associated with alterations in the enteric virome and bacterial microbiome, which may contribute to AIDS-associated enteropathy and disease progression. |
| Databáze: | OpenAIRE |
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