Outcomes of patients with Kaposi's sarcoma who start antiretroviral therapy under routine programme conditions in Malawi
| Autor: | Olesi Pasulani, Mindy Hochgesang, Anthony D. Harries, Erik J Schouten, Simon D Makombe, Joseph Kwong-Leung Yu, Margaret Fitzgerald, Ralf Weigel, Eustice Mhango, Edwin Libamba |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pediatrics
medicine.medical_specialty Malawi Skin Neoplasms Population HIV Infections Malignancy Cohort Studies Acquired immunodeficiency syndrome (AIDS) medicine Humans Sida education Kaposi's sarcoma Sarcoma Kaposi education.field_of_study biology business.industry Mortality rate Public Health Environmental and Occupational Health medicine.disease biology.organism_classification Surgery Infectious Diseases Clinical research Anti-Retroviral Agents Cohort business |
| Zdroj: | Tropical doctor. 38(1) |
| ISSN: | 0049-4755 |
| Popis: | AIDS-associated Kaposi's sarcoma (KS) is the most common AIDS-related malignancy in sub-Saharan Africa, with a generally unfavourable prognosis. We report on six-month and 12-month cohort treatment outcomes of human immunodeficiency virus (HIV)-positive KS patients and HIV-positive non-KS patients treated with antiretroviral therapy (ART) in public sector facilities in Malawi. Data were collected from standardized antiretroviral (ARV) patient master cards and ARV patient registers. Between July and September 2005, 7905 patients started ART-488 (6%) with a diagnosis of KS and 7417 with a non-KS diagnosis. Between January and March 2005, 4580 patients started ART-326 (7%) with a diagnosis of KS and 4254 with a non-KS diagnosis. At six-months and 12-months, significantly fewer KS patients were alive and significantly more had died or defaulted compared to non-KS patients. HIV-positive KS patients on ART in Malawi have worse outcomes than other patients on ART. Methods designed to improve these outcomes must be found. |
| Databáze: | OpenAIRE |
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