Food‐dependent NSAID‐induced hypersensitivity (FDNIH) reactions: Unraveling the clinical features and risk factors
| Autor: | Joan Bartra, Alba García-Moral, Mar Guilarte, Victoria Cardona, Inmaculada Doña, J Sánchez-López, María José Torres, César Picado, Rocío Casas-Saucedo, Giovanna Araujo, Rosa Muñoz-Cano, Mariona Pascal |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty media_common.quotation_subject Immunology Drug allergy Immunoglobulin E Culprit Gastroenterology Drug Hypersensitivity 03 medical and health sciences 0302 clinical medicine Risk Factors Food allergy Internal medicine medicine Humans Immunology and Allergy Overdiagnosis Sensitization Skin Tests media_common biology business.industry Anti-Inflammatory Agents Non-Steroidal Allergens medicine.disease 030104 developmental biology medicine.anatomical_structure 030228 respiratory system biology.protein business Food Hypersensitivity Anaphylaxis |
| Zdroj: | Allergy. 76:1480-1492 |
| ISSN: | 1398-9995 0105-4538 |
| DOI: | 10.1111/all.14689 |
| Popis: | BACKGROUND In up to 70%-80% of patients with a suspected non-steroidal anti-inflammatory drug hypersensitivity (NSAIDH), challenge tests with the culprit drug yield negative results. On the other hand, there could be a NSAIDH overdiagnosis when anaphylaxis is the clinical manifestation. We hypothesize that some negative NSAID challenge tests and an overdiagnosis of NSAIDH occur in patients with food-dependent NSAID-induced hypersensitivity (FDNIH). METHODS We studied 328 patients with a suspected acute NSAIDH. FDNIH was diagnosed in patients meeting all the following: (1) tolerance to the food ingested more temporally closed before the reaction, later the episode, (2) respiratory or cutaneous symptoms or anaphylaxis related to NSAID, (3) positive skin prick test to foods and/or specific IgE to food allergens (Pru p 3, Tri a 19, Pen a 1) involved in the reaction, and (4) negative oral provocation test to the culprit NSAID. RESULTS 199 patients (60%) were diagnosed with NSAIDH and 52 (16%) with FDNIH. Pru p 3 was involved in 44 cases (84.6%) and Tri a 19 in 6 cases (11%). FDNIH subjects were younger (p |
| Databáze: | OpenAIRE |
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