Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease
| Autor: | C Nowakowski, H Benesch, P. Riederer, Louis B. Hersh, Gerhard Ransmayr, Helmut Heinsen, G. Künig |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Pathology medicine.medical_specialty Silver Staining Cell Count Nerve Tissue Proteins Biology Choline O-Acetyltransferase Vestibular nuclei Alzheimer Disease parasitic diseases mental disorders medicine Humans Cholinergic neuron Aged Aged 80 and over Neurons General Neuroscience Vestibular pathway Neurofibrillary tangle Neurofibrillary Tangles Vestibular Nuclei medicine.disease Choline acetyltransferase Lateral vestibular nucleus medicine.anatomical_structure nervous system Female Alzheimer's disease Neuroscience Nucleus Brain Stem |
| Zdroj: | Neuroscience letters. 177(1-2) |
| ISSN: | 0304-3940 |
| Popis: | The lateral vestibular nucleus (LVN, nucleus of Deiters) was examined in the brains of four control subjects and four patients with dementia of the Alzheimer type (DAT). Neuronal counts on sections stained with silver and a polyclonal antibody to human choline acetyltransferase (ChAT) revealed an undiminished number of LVN neurons in patients with DAT. Numerous silver-stained neurofibrillary tangles (NFTs) were found in the DAT group, some also in the LVN of controls. These findings suggest that DAT affects LVN neurons, however without causing neuronal loss. |
| Databáze: | OpenAIRE |
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