Mechanism of production of intestinal secretion by negative luminal pressure
| Autor: | A A Hakim, C B Papeleux, M E Yablonski, N Lifson, J B Lane |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Physiology Venous pressure Chemistry Endocrinology Diabetes and Metabolism Hydrostatic pressure In Vitro Techniques Fluid transport Models Biological Jejunum Intestinal secretion Endocrinology medicine.anatomical_structure Clamp Dogs In vivo Physiology (medical) Internal medicine medicine Hydrostatic Pressure Animals Secretion Venous Pressure Mathematics |
| Zdroj: | The American journal of physiology. 233(5) |
| ISSN: | 0002-9513 |
| Popis: | The relationships between luminal hydrostatic pressure and fluid transport by dog jejunum in vivo studied as a sheet in the Wells clamp were compared with quantitative predictions from a model proposed for the mechanism of the secretion produced by elevated venous pressure. According to the model, the secretion produced by increasing venous pressure and the secretion produced by negative luminal pressure are both passive filtrates contingent on a transepithelial pressure of a few centimeters of H2O. We consider that the agreement between the observed and predicted responses to luminal pressure provides strong support for the model. In particular, a) the observations displayed a predicted gross asymmetry in rates of fluid transfer with isotonic fluids depending on whether the luminal pressure was positive or negative; b) the observed magnitude of the negative luminal pressure required for the onset of secretion agreed with predictions; and c) the secretion contained significant amounts of protein at about 25% of the plasma concentration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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