Iron Measured in Nasal Exudate Samples as a New and Useful Biomarker in the Differential Diagnosis of Patients with Acute Stroke
| Autor: | Lorena Benavente Fernández, Carmen García-Cabo, Pablo Llano-Suárez, Sergio Calleja-Puerta, José M. Costa-Fernández, M.T. Fernández-Abedul |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Exudate
Male medicine.medical_specialty Iron Neurological examination Nose Gastroenterology Proof of Concept Study Diagnosis Differential Predictive Value of Tests Internal medicine medicine Humans Prospective Studies Stroke Aged Ischemic Stroke Aged 80 and over medicine.diagnostic_test Receiver operating characteristic business.industry Reproducibility of Results Exudates and Transudates Middle Aged medicine.disease Neurovascular bundle Hemorrhagic Stroke Lymphatic system Neurology Biomarker (medicine) Female Neurology (clinical) Lymph Differential diagnosis medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Cerebrovascular diseases (Basel, Switzerland). 49(6) |
| ISSN: | 1421-9786 |
| Popis: | Introduction: Differential diagnosis between ischemic and hemorrhagic strokes in the acute stage is one of the major challenges of neurovascular research. Several biomarkers have been studied, but attempts to date have focused on determining their blood levels. Recently, cerebral lymphatic drainage toward the nostrils has been discovered, giving us the chance to study nasal exudate looking for biomarkers of neural damage. We sought to confirm whether iron levels in nasal exudate could identify the hemorrhagic nature of acute stroke. Methods: We studied iron nasal exudate levels in 32 ischemic and 43 hemorrhagic stroke patients. All patients underwent neurological examination assessed by the National Institutes of Health Stroke Scale (NIHSS), brain computed tomography to the differential diagnosis of stroke subtype, laboratory tests, and measurement of iron levels in nasal exudate. Results: The iron levels in nasal exudate were higher in hemorrhagic stroke patients. The area under the receiver operating characteristic curve for ischemic/hemorrhagic stroke discrimination was 0.896 (95% confidence interval 0.823–0.970) and cutoff point of 0.078 nmol/mg (sensitivity 93%, specificity 73%). Conclusions: Our findings suggest that iron levels in nasal exudate may be useful in the acute stage for the differential diagnosis between ischemic and hemorrhagic damage in acute stroke patients. They also open a potential field to study other biomarkers in nasal exudate in several neurological disorders. Clinical studies must be performed to confirm our results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|