Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis

Autor: Jing-Hua Yang, Shu-Ya Wei, Dong-Bao Hu, Yue-Hu Wang, Yun-Song Wang, Hui Yan, Meng-Yuan Xia, Ji-Feng Luo
Rok vydání: 2021
Předmět:
Zdroj: Natural Products and Bioprospecting
ISSN: 2192-2209
2192-2195
DOI: 10.1007/s13659-021-00313-0
Popis: One novel spirolactone, aquilarisinolide (1), three new sesquiterpenoids, (2R,4S,5R,7R)-2-hydroxyeremophila-9,11-dien-8-one (2), (1R,4S,5S,7R,11R)-13-hydroxyepidaphnauran-9-en-8-one (3), and (4R,5S,7R,8S,10S,13R)-8,13-dihydroxyrotunda-1,11-dien-3-one (4), together with 13 known compounds (5–17) were isolated from the resinous heartwood of Aquilaria sinensis (Thymelaeaceae). The structures of the new compounds were elucidated based on the analysis of NMR and MS data and theoretical calculations their ECD spectra. The isolated compounds were evaluated for their protective activities against PC12 cell injury induced by corticosterone (CORT) and 1-methyl-4-phenylpyridine ion (MPP+), as well as inhibitory activities against BACE1. Compound 4, 5,6-dihydroxy-2-(2-phenylethyl)chromone (5), daphnauranol B (7), 6-methoxy-2-[2-(3-methyoxyphenyl)ethyl]chromone (10), isoagarotetrol (14), and 1-hydroxy-1,5-diphenylpentan-3-one (16) showed significant protective effects on CORT-induced injury in PC12 cells at a concentration of 20 μM (P 14) showed a significant protective effect on MPP+-induced injury in PC12 cells at a concentration of 20 μM (P 4 showed a moderate activity (P Graphic Abstract
Databáze: OpenAIRE
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