Long-term, Continuous Treatment with Both Oral and Transdermal Nitrates Increases Cardiac Events in Healed Myocardial Infarction Patients
| Autor: | Ken Kanamasa, Takahiro Hayashi, Akio Kimura, Akiko Ikeda, Kinji Ishikawa, null secondary prevention group |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Time Factors Heart Diseases medicine.medical_treatment Myocardial Infarction Administration Oral 030204 cardiovascular system & hematology Administration Cutaneous Sudden death 03 medical and health sciences 0302 clinical medicine Oral administration medicine Humans 030212 general & internal medicine Dosing Transdermal Chemotherapy Nitrates business.industry Incidence (epidemiology) Middle Aged medicine.disease Heart failure Anesthesia Female Isosorbide dinitrate Cardiology and Cardiovascular Medicine business Follow-Up Studies medicine.drug |
| Zdroj: | Angiology. 53:399-408 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331970205300405 |
| Popis: | This study was performed to investigate the effects of continuous dosing of oral, trans dermal (patch), and a combination of the two with nitrate treatments on cardiac events in patients with healed myocardial infarction. In total, 1,291 patients with healed myocardial infarction were assigned 2 groups: treatment with nitrates (n = 713) or nontreatment (n = 578). Nitrate treatment was subdivided into 3 groups: patch group (n =149), oral group (n = 504), and combination group (n = 60). The mean observation period was 17.4 ±21.1 months. Primary end points were nonfatal and fatal recurrent myocardial infarction, death from congestive heart failure, and sudden death. Baseline characteristics were also compared among the 4 groups to determine any effects on outcome. Among the patients with patch, oral, and combination groups, cardiac events occurred 3.4%, 6.7%, 10.0%, respectively, whereas only 2.9% of the patients treated without nitrates had cardiac events. The incidence of cardiac events was significantly greater in patients with oral nitrates and combination groups compared to patients without nitrates (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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