Substances derived from 4-de-N-methylfortimicin B

Autor:	Momir Cirovic, Ruth S. Stanaszek, Paul Kurath, Richard S. Egan, William H. Washburn, James E. Leonard, Dave Grampovnik, Paulette Johnson, Jack Tadanier
Rok vydání:	1981
Předmět:	Pharmacology Chemistry Aminoglycosides Magnetic Resonance Spectroscopy Chemical Phenomena Stereochemistry Drug Discovery Molecular Conformation Biological activity Antibacterial activity Anti-Bacterial Agents
Zdroj:	The Journal of Antibiotics. 34:691-700
ISSN:	1881-1469 0021-8820
DOI:	10.7164/antibiotics.34.691
Popis:	The preparation of 4-de-N-methylfortimicin A analogs as well as the preparation of 4-de-N-methyl-4-N-(beta-aminoethyl)-4-N-ethylfortimicin B is reported. It was shown that the 4-N-methyl group in fortimicin analogs is essential for antibacterial activity since neither the 4-de-N-methylfortimicin A nor the 4-de-N-methyl-4-N-(beta-aminoethyl)-4-N-ethylfortimicin B exhibited useful biological activity.
Databáze:	OpenAIRE
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