Histopathologic features in esophagomyotomy specimens from patients with achalasia
| Autor: | John R. Goldblum, Joel E. Richter, Thomas W. Rice |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Intramucosal Adenocarcinoma Myenteric Plexus Achalasia Inflammation Adenocarcinoma Esophagus Fibrosis Pressure medicine Humans Aged Hepatology Esophageal disease business.industry Gastroenterology Muscle Smooth Middle Aged medicine.disease Ganglion Esophageal Achalasia Esophagectomy medicine.anatomical_structure Female Ganglia Esophagogastric Junction sense organs medicine.symptom business |
| Zdroj: | Gastroenterology. 111:648-654 |
| ISSN: | 0016-5085 |
| Popis: | A previous study evaluating the morphological features of esophagi resected for endstage achalasia showed marked depletion of myenteric ganglion cells, widespread destruction of nerves, and variable chronic inflammation. The aim of this study was to evaluate the histological features in esophagomyotomy specimens from 11 patients with early achalasia, defined as minimal to moderate esophageal dilation without sigmoid deformity.The histological features of esophagomyotomy specimens from 11 patients with achalasia were analyzed and compared with the findings of control specimens obtained from 8 patients who underwent esophagectomy for intramucosal adenocarcinoma.Control specimens had normal numbers of ganglion cells (0.70-0.91 ganglion cells per high-power field) and minimal inflammation. Three patients with vigorous achalasia had normal ganglion cell numbers (0.79-0.91 ganglion cells per high-power field) and at least mild myenteric inflammation without neural fibrosis. The remaining 8 patients had few or no ganglion cells (0-0.30 ganglion cells per high-power field) and at least mild myenteric inflammation and neural fibrosis. Ganglionitis was found in 2 cases. Ganglion cell number was inversely correlated with degree of myenteric neural fibrosis (P0.001).Vigorous achalasia has pathological features that are distinct from classic achalasia. The earliest pathological changes consist of myenteric inflammation with injury to and subsequent loss of ganglion cells and injury to and fibrosis of myenteric nerves. |
| Databáze: | OpenAIRE |
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