Autoantibodies, C-reactive protein, erythrocyte sedimentation rate and serum cytokine profiling in monitoring of early treatment
| Autor: | Małgorzata Sochocka-Bykowska, Maria Szarecka, Edyta Brzustewicz, Ewa Bryl, Izabella Henc, Agnieszka Daca, Jacek M. Witkowski |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
rheumatoid arthritis
0301 basic medicine disease monitoring medicine.medical_treatment Immunology lcsh:Medicine Disease 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy 030203 arthritis & rheumatology biology medicine.diagnostic_test business.industry lcsh:R C-reactive protein Acute-phase protein Autoantibody biomarkers medicine.disease cytokines 030104 developmental biology Cytokine Rheumatoid arthritis Erythrocyte sedimentation rate biology.protein Clinical Immunology Tumor necrosis factor alpha undifferentiated arthritis business |
| Zdroj: | Central European Journal of Immunology, Vol 42, Iss 3, Pp 259-268 (2017) Central-European Journal of Immunology |
| ISSN: | 1426-3912 |
| Popis: | Introduction: Currently used clinical scale and laboratory markers to monitor patients with early rheumatoid arthritis (RA) seem to be not sufficient. It has been demonstrated that disease- related cytokines may be elevated very early in RA development and cytokines are considered as the biomarkers potentially useful for RA monitoring. Material and methods : The group of patients with undifferentiated arthritis (UA) developing RA (UA→RA) was identified from a total of 121 people with arthralgia. UA→RA (n = 16) and healthy control (n = 16) subjects underwent clinical and laboratory evaluation, including acute phase reactants (APRs) and autoantibodies. Cytokines IFN-γ, IL-10, TNF, IL-17A, IL-6, IL-1b, IL-2 in sera were assayed using flow cytometric bead array test. Results : 34.5% of patients with UA developed RA. DAS28 reduced as early as 3 months after initiation of treatment. No DAS28 difference between groups of autoantibody (RF, anti-CCP, ANA-HEp-2) -positive and -negative patients was observed, however, comparing groups of anti-CCP and RF-double negative and -double positive patients, the trend of sooner clinical improvement was visible in the second abovementioned group. After the treatment introduction, the ESR level reduced significantly, while CRP level reduction was not significant. Serum cytokine levels of IL-10, IL-6 and IL-17A reduced after 6 months since introduction of treatment. The positive correlations between ESR, CRP and specific cytokine levels were observed. Conclusions : The autoantibody and APR profile is poorly connected with the RA course. The serum cytokine profile change in the course of RA and may be potentially used for optimization of RA monitoring. |
| Databáze: | OpenAIRE |
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