Novel method to assess intrinsic heart rate recovery in ambulatory ECG recordings tracks cardioprotective effects of chronic autonomic regulation therapy in patients enrolled in the ANTHEM‐HF study
| Autor: | Badri Amurthur, Imad Libbus, Bruce H. KenKnight, Richard L. Verrier, Gerrard M. Carlson |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Vagus Nerve Stimulation medicine.medical_treatment 030204 cardiovascular system & hematology Intrinsic heart rate Autonomic Nervous System Autonomic regulation 03 medical and health sciences 0302 clinical medicine Heart Rate Physiology (medical) Internal medicine Heart rate medicine Humans In patient heart rate recovery Aged autonomic reflexes Heart Failure Ejection fraction business.industry autonomic regulation therapy General Medicine Original Articles Middle Aged medicine.disease baroreflex sensitivity Ambulatory ECG Treatment Outcome Heart failure Anesthesia Cardiology Electrocardiography Ambulatory Exercise Test Original Article Female Cardiology and Cardiovascular Medicine business human activities 030217 neurology & neurosurgery Vagus nerve stimulation |
| Zdroj: | Annals of Noninvasive Electrocardiology : The Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc |
| ISSN: | 1542-474X 1082-720X |
| Popis: | Background Postexercise heart rate recovery (HRR) is a powerful and independent predictor of mortality. Autonomic regulation therapy (ART) with chronic vagus nerve stimulation (VNS) has been shown to improve ventricular function in patients with chronic heart failure. However, the effect of ART on HRR in patients with heart failure remains unknown. Methods A new measure involving quantification of intrinsic HRR was developed for 24-hr ambulatory ECG (AECG) recordings based on spontaneous heart rate changes observed during daily activity in patients with symptomatic heart failure and reduced ejection fraction. Intrinsic HRR values were compared in 21 patients enrolled in the ANTHEM-HF study (NCT01823887) before and after 12 months of chronic ART (10 Hz, 250 μs pulse width, 18% duty cycle, maximum tolerable current amplitude after 10 weeks of titration) and to values from normal subjects (PhysioNet database, n = 54). Results With chronic ART, average intrinsic HRR was improved as indicated by a shortening of the rate-recovery time constant by 8.9% (from 12.3 ± 0.1 at baseline to 11.2 ± 0.1 s, p |
| Databáze: | OpenAIRE |
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