Cost utility of allogeneic stem cell transplantation with matched unrelated donor versus treatment with imatinib for adult patients with newly diagnosed chronic myeloid leukaemia
| Autor: | Lusine Breitscheidel |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Cost-Benefit Analysis Antineoplastic Agents Newly diagnosed Chronic myeloid leukaemia Piperazines Young Adult Germany hemic and lymphatic diseases medicine Humans Transplantation Homologous health care economics and organizations business.industry Health Policy Imatinib Matched Unrelated Donor Markov Chains Surgery Transplantation Pyrimidines Leukemia Myeloid Cost utility Benzamides Chronic Disease Cohort Imatinib Mesylate Quality-Adjusted Life Years Stem cell business Stem Cell Transplantation medicine.drug |
| Zdroj: | Journal of Medical Economics. 11:571-584 |
| ISSN: | 1941-837X 1369-6998 |
| DOI: | 10.3111/13696990802354683 |
| Popis: | To estimate, from the perspective of the German statutory health insurance, the cost utility of allogeneic stem cell transplantation with matched unrelated donor (MUD-SCT) in newly diagnosed, chronic-phase chronic myeloid leukaemia (CML) patients aged 40 years or younger, relative to the treatment with imatinib.The incremental cost-effectiveness ratio (ICER) of the additional cost of imatinib versus MUD-SCT per quality-adjusted life year (QALY) gained was chosen as a target assessment. ICER was quantified using a Markov cohort modelling approach. The evaluation encompassed 5 years of treatment with either approach, and only direct medical costs (in euro, year 2005) were considered.There were incremental costs of euro77,410 for imatinib therapy per QALY gained versus MUD-SCT. No strategy was clearly dominant; on average, during 5 years, cost savings of euro63,433 were obtained and 0.82 QALY lost by SCT compared to treatment with imatinib. QALYs gained in CML patients with either treatment resulted in considerable cost to the third-party payer in Germany. The results were particularly sensitive to the price of imatinib.The analysis finds that imatinib is more costly but more effective (as measured in QALYs) over a 5-year time horizon. The resulting ICER of euro77,410 per QALY is higher than commonly cited thresholds. The cost utility of MUD-SCT to treat CML in patients with a European Group for Blood and Marrow Transplantation scoreor = to 2 compares with that of the imatinib strategy. |
| Databáze: | OpenAIRE |
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