Characteristics of 10-year survivors of high-grade serous ovarian carcinoma

Autor: Anil K. Sood, Douglas A. Levine, Robert L. Coleman, Scott McMeekin, Jenny Lester, Alpa M. Nick, Beth Y. Karlan, Susan K. Lutgendorf, Fanny Dao, Kathleen N. Moore, Jill Tseng, Brooke A. Schlappe
Rok vydání: 2016
Předmět:
0301 basic medicine
Survival
Serous carcinoma
Genes
BRCA2
Genes
BRCA1
Pilot Projects
0302 clinical medicine
Ovarian carcinoma
Obstetrics and Gynaecology
80 and over
Survivors
Outcome
Cancer
Aged
80 and over
Ovarian Neoplasms
Obstetrics and Gynecology
Middle Aged
Serous fluid
medicine.anatomical_structure
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Cohort
Female
Adult
medicine.medical_specialty
Oncology and Carcinogenesis
Cystadenocarcinoma
and over
Neoadjuvant chemotherapy
Article
Paediatrics and Reproductive Medicine
03 medical and health sciences
Long-term survival
Rare Diseases
Median follow-up
Ovarian cancer
Clinical Research
Internal medicine
medicine
Humans
Stage IIIC
Oncology & Carcinogenesis
Germ-Line Mutation
Aged
business.industry
Serous
medicine.disease
BRCA1
BRCA2
United States
Surgery
Cystadenocarcinoma
Serous
030104 developmental biology
Good Health and Well Being
Genes
Neoplasm Grading
business
Surgical cytoreduction
Fallopian tube
Zdroj: Gynecologic oncology, vol 141, iss 2
Dao, F; Schlappe, BA; Tseng, J; Lester, J; Nick, AM; Lutgendorf, SK; et al.(2016). Characteristics of 10-year survivors of high-grade serous ovarian carcinoma. GYNECOLOGIC ONCOLOGY, 141(2), 260-263. doi: 10.1016/j.ygyno.2016.03.010. UCLA: Retrieved from: http://www.escholarship.org/uc/item/78n7q01f
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2016.03.010
Popis: ObjectiveHigh-grade serous carcinoma (HGSC) generally presents at an advanced stage with poor long-term (LT) survival. Here we describe clinical features found in women surviving HGSC for ten or more years.MethodsA multi-center research consortium was established between five participating academic centers. Patient selection criteria included high-grade serous ovarian, fallopian tube, or peritoneal carcinoma with at least ten years of follow up. Non-serous, borderline tumors and low-grade serous subtypes were excluded.ResultsThe 203 identified LT ten-year survivors with HGSC were diagnosed at a median age of 57years (range 37–84years). The majority of patients had stage IIIC (72.4%) disease at presentation. Of those who underwent primary cytoreductive surgery, optimal cytoreduction was achieved in 143 (85.6%) patients. After a median follow up of 144months, 88 (46.8%) patients did not develop recurrent disease after initial treatment. Unexpected findings from this survey of LT survivors includes 14% of patients having had suboptimal cytoreduction, 11% of patients having an initial platinum free interval of
Databáze: OpenAIRE
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