Effect of Footprint Preparation on Tendon-to-Bone Healing: A Histologic and Biomechanical Study in a Rat Rotator Cuff Repair Model
| Autor: | Ken-ichi Matsuda, Ryuhei Furukawa, Mitsuhiro Kawata, Haruhiko Nakagawa, Yukichi Kabuto, Toru Morihara, Toshikazu Kubo, Yoshikazu Kida, Masaki Tanaka, Tsuyoshi Sukenari, Hiroyoshi Fujiwara, Yuji Arai |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Bone Marrow Cells Bone healing Arthroplasty Rotator Cuff Injuries Rats Sprague-Dawley Tendons 03 medical and health sciences Random Allocation 0302 clinical medicine medicine Animals Orthopedics and Sports Medicine Rotator cuff 030222 orthopedics Wound Healing business.industry Rotator cuff injury 030229 sport sciences Anatomy medicine.disease Surgery Tendon Biomechanical Phenomena Rats Disease Models Animal medicine.anatomical_structure Fibrocartilage business Wound healing Cancellous bone Greater Tuberosity |
| Zdroj: | Arthroscopy : the journal of arthroscopicrelated surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 33(8) |
| ISSN: | 1526-3231 |
| Popis: | Purpose To compare the histologic and biomechanical effects of 3 different footprint preparations for repair of tendon-to-bone insertions and to assess the behavior of bone marrow–derived cells in each method of insertion repair. Methods We randomized 81 male Sprague-Dawley rats and green fluorescent protein–bone marrow chimeric rats into 3 groups. In group A, we performed rotator cuff repair after separating the supraspinatus tendon from the greater tuberosity and removing the residual tendon tissue. In group B, we also drilled 3 holes into the footprint. The native fibrocartilage was preserved in groups A and B. In group C, we excavated the footprint until the cancellous bone was exposed. Histologic repair of the tendon-to-bone insertion, behavior of the bone marrow–derived cells, and ultimate force to failure were examined postoperatively. Results The areas of metachromasia in groups A, B, and C were 0.033 ± 0.019, 0.089 ± 0.022, and 0.002 ± 0.001 mm 2 /mm 2 , respectively, at 4 weeks and 0.029 ± 0.022, 0.090 ± 0.039, and 0.003 ± 0.001 mm 2 /mm 2 , respectively, at 8 weeks. At 4 and 8 weeks postoperatively, significantly higher cartilage matrix production was observed in group B than in group C (4 weeks, P = .002; 8 weeks, P P = .031). Conclusions Drilling into the footprint and preserving the fibrocartilage improved the quality of repair tissue and biomechanical strength at the tendon-to-bone insertion after rotator cuff repair in an animal model. Clinical Relevance Drilling into the footprint and preserving the fibrocartilage can enhance repair of tendon-to-bone insertions. This method may be clinically useful in rotator cuff repair. |
| Databáze: | OpenAIRE |
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