Small-Molecule Inhibition of Bacterial Biofilm
| Autor: | Narayansaswamy Jayaraman, Anirban Ghosh, Dipankar Chatterji |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
biology
Multidrug tolerance medicine.drug_class Host (biology) General Chemical Engineering Antibiotics Biofilm Pathogenic bacteria General Chemistry Mini-Review medicine.disease_cause biology.organism_classification Microbiology Chronic infection Chemistry Antibiotic resistance medicine QD1-999 Bacteria |
| Zdroj: | ACS Omega, Vol 5, Iss 7, Pp 3108-3115 (2020) ACS Omega |
| ISSN: | 2470-1343 |
| Popis: | Antibiotic resistance is a massive and serious threat to human welfare and healthcare. Apart from being genetically resistant to antibiotics, the other important mechanism by which bacteria can evade antibiotics is multidrug tolerance. Here cells enter into a transiently nongrowing phase, and as a result, latent infection remains inside the host, causing disease recurrence. Biofilm-derived antibiotic tolerance and persister formation of the pathogenic bacteria inside the host remain a serious issue of treatment failure and recurrent chronic infection in the case of all major pathogens. As a result, new chemotherapeutic agents are sought that specifically inhibit biofilm formation or maturation as well as cause the dispersion of mature biofilms, thus allowing the conventional drugs to kill sensitive cells residing inside. This mini-review attempts to analyze different small-molecule-based chemical approaches that have been used to enable bacterial biofilm inhibition at different steps of maturation. |
| Databáze: | OpenAIRE |
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