No acute effects of an exposure to 50 ppm methyl methacrylate on the upper airways
| Autor: | Otfried Mayer-Popken, Stephan Letzel, Andreas Faldum, C. Zagar, Detlev Jung, Jürgen Brieger, Bernd Roßbach, Axel Muttray, Jan Gosepath, Wolf J. Mann |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Methylmethacrylate medicine.disease_cause Young Adult chemistry.chemical_compound Germany Internal medicine Olfactory threshold medicine Humans RNA Messenger Interleukin 8 Methyl methacrylate Nose Inhalation Exposure No-Observed-Adverse-Effect Level Cross-Over Studies Inhalation Public Health Environmental and Occupational Health Interleukin Epithelial Cells Olfactory Perception Crossover study Healthy Volunteers Nasal Mucosa medicine.anatomical_structure Endocrinology chemistry Mucociliary Clearance Prostaglandin-Endoperoxide Synthases Sensory Thresholds Anesthesia Cytokines Nasal Absorption Irritation |
| Zdroj: | International Archives of Occupational and Environmental Health. 88:1043-1051 |
| ISSN: | 1432-1246 0340-0131 |
| Popis: | The German MAK value of methyl methacrylate has been fixed at 50 ppm. The aim of this study was to evaluate possible acute effects of an exposure to 50 ppm methyl methacrylate on the upper airways of human subjects. Twenty healthy subjects were exposed to 50 ppm methyl methacrylate and to air (sham) in an exposure chamber for 4 h according to a crossover design. Symptoms were assessed by the SPES questionnaire. Olfactory thresholds for n-butanol and mucociliary transport time were measured before and after exposure. Concentrations of interleukin 1s and interleukin 8 were determined in nasal secretions taken after exposure. mRNA levels of interleukins 1s, 6 and 8, tumor necrosis factor α, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1, and cyclooxygenases 1 and 2 were measured in nasal epithelial cells, obtained after exposure. Possible effects were investigated by semiparametric and parametric crossover analyses. The score of the item “irritation to the nose” was slightly elevated following exposure to methyl methacrylate (p ≤ 0.01). Olfactory functioning was not impaired. Mucociliary transport time did not change. Neither concentrations of interleukins in nasal secretions nor mRNA levels were elevated. Only minor irritating effects on the nose were observed. The acute exposure to 50 ppm methyl methacrylate did not cause any adverse effects. However, the results cannot be extrapolated to chronic exposure. |
| Databáze: | OpenAIRE |
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