Effects of dietary administration of 5-(3,4-dichlorophenyl)-5-ethylbarbituric acid (dichlorophenobarbital) to rats: Emphasis on hepatic drug-metabolizing enzymes and morphology
| Autor: | N.V. Owen, Robert C. Anderson, D.G. Hoffman, William J. Griffing, W.R. Gibson |
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| Rok vydání: | 1971 |
| Předmět: |
Male
Drug medicine.medical_specialty media_common.quotation_subject Thyroid Gland Anisoles Biology Toxicology Muscle hypertrophy Internal medicine medicine Animals media_common Pharmacology chemistry.chemical_classification Endoplasmic reticulum Body Weight Thyroid Organ Size Metabolism Nitro Compounds Stimulation Chemical Rats Microscopy Electron Drug metabolizing enzymes medicine.anatomical_structure Enzyme Endocrinology Liver chemistry Dealkylation Enzyme Induction Phenobarbital Barbiturates Microsomes Liver Microsome Female Chlorine Hepatomegaly |
| Zdroj: | Toxicology and Applied Pharmacology. 18:720-733 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/s0041-008x(71)80027-3 |
| Popis: | Dietary administration of 5-(3,4-dichlorophenyl)-5-ethylbarbituric acid (0.002–0.054% drug diets) to rats for 30 days resulted in centrilobular hypertrophy of hepatocytes and dose-related increases in liver weight, hepatic microsomal protein, and the rate of p -nitroanisole O-demethylation in liver homogenates. The increase in microsomal protein was evident by electron microscopy as an increased amount of smooth endoplasmic reticulum. When rats were returned to a control diet for 2 weeks after treatment, liver weight, the concentration of microsomal protein, and the rate of p -nitroanisole metabolism were comparable to control values. Hypertrophy of the thyroid observed at the end of treatment was reversible upon withdrawal of dichlorophenobarbital. The results demonstrated that dichlorophenobarbital is a potent inducer of hepatic drug-metabolizing enzymes, and that most of the effects are rapidly reversible upon cessation of treatment. |
| Databáze: | OpenAIRE |
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