Reactions of Nitroxides, Part 17. Synthesis, Fungistatic and Bacteriostatic Activity of Novel Five- and Six-Membered Nitroxyl Selenoureas and Selenocarbamates
| Autor: | Jarosław Hupko, Jerzy Zakrzewski, Bogumiła Huras, Maria Krawczyk, Anna Kiełczewska, Katarzyna Jaszczuk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Antifungal
Antifungal Agents medicine.drug_class Pharmaceutical Science Microbial Sensitivity Tests Pyrrolidine Article Analytical Chemistry selenocarbamates lcsh:QD241-441 chemistry.chemical_compound Organoselenium Compound bacteriostatic activity lcsh:Organic chemistry organoselenium compounds Drug Discovery medicine Moiety Organic chemistry Urea Physical and Theoretical Chemistry fungistatic activity biology Bacteria Chemistry Organic Chemistry Fungi Nitroxyl biology.organism_classification Anti-Bacterial Agents Chemistry (miscellaneous) Molecular Medicine Nitrogen Oxides Piperidine Carbamates selenoureas Antibacterial activity |
| Zdroj: | Molecules, Vol 24, Iss 13, p 2457 (2019) Molecules Volume 24 Issue 13 |
| ISSN: | 1420-3049 |
| Popis: | The reactions of 3-isoselenocyanato-2,2,5,5-tetramethylpyrrolidine-1-oxyl, 3-isoselenocyanatomethyl-2,2,5,5-tetramethyl-3-pyrrolidine-1-oxyl, and 4-isoselenocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl with selected amines and alcohols give the corresponding novel nitroxyl selenoureas and selenocarbamates, all bearing a nitroxyl moiety. Synthesized selenoureas and selenocarbamates show significant activity against pathogenic fungi and bacteria. In contrast to piperidine nitroxides, pyrrolidine, five-membered nitroxyl selenoureas and selenocarbamates show excellent antifungal and antibacterial activity against pathogenic fungi and bacteria, respectively. |
| Databáze: | OpenAIRE |
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