Remote alkylation of N-(quinolin-8-yl)benzamides with alkyl bromides via ruthenium(ii )-catalyzed C–H bond activation
| Autor: | Masilamani Jeganmohan, Krishna Mohan Das, Arumugam Mariappan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
C h bond 010405 organic chemistry Organic Chemistry Quinoline chemistry.chemical_element Alkylation 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis Ruthenium chemistry.chemical_compound chemistry Deuterium lipids (amino acids peptides and proteins) Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Organic & Biomolecular Chemistry. 16:3419-3427 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c8ob00581h |
| Popis: | A ruthenium(ii) catalyzed remote C-5 alkylation of the quinoline ring of N-(quinolin-8-yl)benzamides with alkyl bromides via C-H bond activation is described. Various substituted N-(quinolin-8-yl)benzamides reacted with tertiary or secondary or primary alkyl bromides giving the alkylated products in good to moderate yields. Herein, the ruthenium catalyzed remote C-5 alkylation is effected via aromatic C-H bond activation as a key step. It has been proved by the deuterium labelling studies and mechanistic investigations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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