Disposable devices for the dispensing of oral drops. Study of photoprotectiveness and compatibility
| Autor: | André Gayte-Sorbier, Christine Machou, Charles B. Airaudo, Bruno Pion, Matthieu Froissart |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Fluphenazine
Preservative Light Drug Storage Biomedical Engineering Biophysics Administration Oral Color Biocompatible Materials Bioengineering Thioridazine Cyamemazine Biomaterials Levomepromazine chemistry.chemical_compound Drug Delivery Systems Drug Stability Phenothiazines medicine Disposable Equipment Alimemazine Thioproperazine Binding Sites Chromatography business.industry chemistry business Oxidation-Reduction Pipotiazine Antipsychotic Agents medicine.drug |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 7:381-388 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1163/156856295x00391 |
| Popis: | Amber-coloured syringes designed for the distribution of unit-doses of oral drops were studied for the efficiency of the photoprotectiveness and the possible binding of eleven phenothiazine neuroleptics: alimemazine, chlorpromazine, cyamemazine, fluphenazine, levomepromazine, periciazine, pipotiazine, prochlorperazine, thioproperazine, thioridazine, and trifluoperazine, all very easily oxidized in solution in daylight. Spectrofluorimetry made it possible, in one operation, to determine the remaining concentrations of drugs after storage and to verify the absence of photo-oxidation. The storage was performed up to 13 days at 25 +/- 3 degrees C and without any precaution from daylight. All the drugs studied were stable and none bound on the syringes. However, the stability appeared to be due to the antioxidants in the drug preparations, and not to the coloured material, since oral drops were also stable in uncoloured syringes designed for injection. Nevertheless, the amber-coloured syringes efficiently protect the active principles in pure aqueous solutions, without preservative, and thus this physical protection reinforces the chemical one of the galenical formulation. |
| Databáze: | OpenAIRE |
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