Drug eluting stents based on Poly(ethylene carbonate): optimization of the stent coating process
| Autor: | Marc Kalinowski, Holger Petersen, Regina Reul, Catherine Curdy, Jürgen Janek, Nadja Bege, Thomas Kissel, Sebastian Klaus, Sven Ole Steinmüller |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Ethylene Oxide
medicine.medical_specialty Biocompatibility Paclitaxel Polymers medicine.medical_treatment Pharmaceutical Science engineering.material Diffusion Excipients chemistry.chemical_compound Coating Coated Materials Biocompatible In vivo Absorbable Implants medicine Ethylene carbonate Drug Carriers Chemistry Stent Drug-Eluting Stents Thrombosis General Medicine equipment and supplies Surgery Kinetics Drug-eluting stent Delayed-Action Preparations engineering Swelling medicine.symptom Polyethylenes Biotechnology Biomedical engineering |
| Zdroj: | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 80(3) |
| ISSN: | 1873-3441 |
| Popis: | First generation drug eluting stents (DES) show a fivefold higher risk of late stent thrombosis compared to bare metal stents. Therefore, new biodegradable and biocompatible polymers for stent coating are needed to reduce late stent thrombosis. In this study, a reproducible spray-coating process for stents coated with Poly(ethylene carbonate), PEC, and Paclitaxel was investigated. PEC is a biocompatible, thermoelastic polymer of high molecular weight. The surface degradation of PEC is triggered by superoxide anions produced by polymorphonuclear leukocytes and macrophages during inflammatory processes. Stents with different drug loading were reproducibly produced by a spray-coating apparatus. Confocal laser scanning micrographs of fluorescent dye loaded stents were made to investigate the film homogeneity. The abluminal stent site was loaded more than the luminal site, which is superior for DES. The deposition of the layers was confirmed by TOF-SIMS investigations. Referring to the stent surface, the drug loading is 0.32 μg (±0.05) (once coated), 0.53 μg (±0.11) (twice coated), or 0.73 μg (±0.06) (three times coated) Paclitaxel per mm2 stent surface. The in vitro release mechanism during non-degradation conditions can be explained by diffusion-controlled drug release slightly influenced by swelling of PEC, revealing that 100% of the loaded Paclitaxel will be released via diffusion within 2 months. So, the in vivo release kinetic is a combination of diffusion-controlled drug release and degradation-controlled drug release depending on the presence or absence of superoxide anions and accordingly depending on the presence or absence of macrophages. We conclude that the specific release kinetics of PEC, its biocompatibility, and the favorable mechanical properties will be beneficial for a next generation drug eluting stent meriting further investigations under in vivo conditions. |
| Databáze: | OpenAIRE |
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