Pharmacological inhibition of TR?1 receptor potentiates the thyroxine effect on body weight reduction in rats: potential therapeutic implications in controlling body weight
| Autor: | Ch. Xinaris, Panagiotis Moraitis, Vassiliki Malliopoulou, Constantinos Pantos, Ioannis Paizis, Dennis V. Cokkinos, Iordanis Mourouzis, Alexandros D. Cokkinos |
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| Rok vydání: | 2007 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Amiodarone Pharmacology Eating Endocrinology Internal medicine Weight Loss Internal Medicine medicine Animals Rats Wistar Thyroid hormone binding Receptor Dronedarone Thyroid hormone receptor business.industry Thyroid Drug Synergism medicine.disease Obesity Rats Thyroxine medicine.anatomical_structure business Thyroid Hormone Receptors alpha medicine.drug Hormone |
| Zdroj: | Diabetes, Obesity and Metabolism. 9:136-138 |
| ISSN: | 1463-1326 1462-8902 |
| DOI: | 10.1111/j.1463-1326.2006.00587.x |
| Popis: | It has been previously reported that thyroid hormone receptor alpha1 (TRalpha1) is involved in the regulation of food intake and heart rhythm. Herein, we show that pharmacological inhibition of TRalpha1 by dronedarone, an amiodarone like compound (shown to antagonize thyroid hormone binding to TRalpha1), prevented the thyroid hormone induced increase in food intake and heart rate acceleration in rats. This resulted in a marked reduction in body weight. It is likely that thyroid analogs may prove potential therapeutic agents for controlling body weight. |
| Databáze: | OpenAIRE |
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