Reactivity of Small Vessels from Mature to Senescent Female Rabbits
| Autor: | Thomas Lon Owen |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Aging
medicine.medical_specialty Vascular smooth muscle Physiology Biology Peptide hormone Muscle Smooth Vascular Norepinephrine Internal medicine medicine Animals Lagomorpha Angiotensin II Muscles Skeletal muscle Ear biology.organism_classification Propranolol Femoral Artery Endocrinology medicine.anatomical_structure Circulatory system Female Rabbits medicine.symptom Cardiology and Cardiovascular Medicine Histamine Muscle Contraction Muscle contraction Blood vessel Artery |
| Zdroj: | Journal of Vascular Research. 22:172-178 |
| ISSN: | 1423-0135 1018-1172 |
| DOI: | 10.1159/000158599 |
| Popis: | In order to determine if there are differences in reactivity of small arteries of cutaneous and skeletal muscle vascular beds taken from rabbits of different ages, vascular smooth muscle strips were tested in vitro with a variety of drugs. Arteries from the ear and hind limb skeletal muscle were removed from adult female rabbits, aged 6–48 months. Developed force of the vessel strips was measured during exposure to cumulative concentrations of norepinephrine, norepinephrine following propranolol, angiotensin II (skeletal muscle artery only) and histamine (ear artery only). Comparable segments of arteries from rabbits of different ages showed no significant differences in size or in maximum developed force attributable to age. A lack of beta-adrenoceptor activity was indicated in the ear arteries of all adult age groups studied, while propranolol enhanced contractile responses to norepinephrine in skeletal muscle arteries independent of age. Likewise, there were no consistent, age-related changes in the reactivity of either vessel type to norepinephrine, histamine, or angiotensin. This study indicates that small cutaneous and skeletal muscle arteries from mature female rabbits do not undergo any appreciable change in adrenergic and nonadrenergic sensitivity with age. |
| Databáze: | OpenAIRE |
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