Endothelial dysfunction and oxidative stress in type 1 and type 2 diabetic patients without clinical macrovascular complications
| Autor: | Elisabetta Mandosi, Susanna Morano, Oriana Laurenti, Rosalba Cipriani, Arianna Moretti, Maria Cristina Bravi, Giancarlo De Mattia, Alessandra Gatti |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Endocrinology Diabetes and Metabolism Urinary system medicine.disease_cause endothelial dysfunction glutathione redox system chemistry.chemical_compound Endocrinology Von Willebrand factor Reference Values Internal medicine Diabetes mellitus Internal Medicine medicine Humans oxidative stress Endothelial dysfunction Diabetic Retinopathy Endothelin-1 biology business.industry General Medicine Diabetic retinopathy Middle Aged medicine.disease Glutathione von willebrand factor Vascular endothelial growth factor Diabetes Mellitus Type 1 Blood pressure Diabetes Mellitus Type 2 chemistry biology.protein Female Endothelium Vascular business Biomarkers Oxidative stress |
| Popis: | Aims: To evaluate the relationship between oxidative stress and endothelial dysfunction (ED) in diabetic patients without clinical macrovascular complications. Methods: In 27 type 1, 56 type 2 diabetic patients and 35 healthy controls the redox state (GSH, GSSG; enzymatic method), endothelin-1 (ET-1; ELISA) and von Willebrand factor (vWF; ELISA) plasma levels, urinary vascular endothelial growth factor (VEGF; ELISA) were measured. Results: Decreased GSH levels (p < 0.05, type 1 and type 2), GSH/GSSG ratio (p < 0.05 type 1, p < 0.001 type 2) and elevated vWF levels (p < 0.001, type 1 and type 2) were observed in diabetic patients in comparison with controls. A negative correlation between GSH and vWF (p < 0.02 and p < 0.001, in type 1 and type 2, respectively) and GSH and BMI (p < 0.02 in type 1 and type 2) was observed. ET-1 was positively correlated to age (p < 0.05) and diabetes duration (p < 0.03) in type 1, while vWF was correlated to systolic blood pressure (p < 0.05) in type 2 diabetic patients. Urinary VEGF was higher in type 2 (p < 0.05) in comparison with type 1 diabetic patients and was correlated to glycemia (p < 0.05) and systolic blood pressure (p < 0.05). Conclusions: These data might indicate that markers of oxidative stress and ED are altered in diabetic patients without clinical macrovascular complications. |
| Databáze: | OpenAIRE |
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