Non-effect of p22-phox -930A/G polymorphism on end-organ damage in Brazilian hypertensive patients
| Autor: | Wilson Nadruz, Mônica Siqueira Ferreira, Maria Cecília Jayme Bueno Gallani, Kleber G. Franchini, ML Sales, Licio A. Velloso, R C R Colombo, Cid A. Leme |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Polymorphism Genetic End organ damage business.industry viruses NADPH Oxidases Middle Aged medicine.disease Kidney Oxidative Stress Endocrinology Internal medicine parasitic diseases Hypertension Internal Medicine medicine Humans Female Hypertrophy Left Ventricular business Promoter Regions Genetic geographic locations Brazil |
| Zdroj: | Journal of human hypertension. 21(6) |
| ISSN: | 0950-9240 |
| Popis: | The p22-phox subunit is an essential component of NAD(P)H oxidase enzymatic complex, which is considered the major source of oxidative stress products in the cardiovascular system. The -930G allele of p22-phox has been associated with higher promoter activity, increased NAD(P)H oxidase-mediated oxidative stress and hypertension. We recently reported that left ventricular hypertrophy is accompanied by increased myocardial p22-phox expression in aortic-banded rats, suggesting that this protein might be involved in hypertensive cardiac hypertrophy. |
| Databáze: | OpenAIRE |
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