| Zdroj: |
Wang, Q, Richardson, T G, Sanderson, E C M, Ala-Korpela, M J, Davey Smith, G & Holmes, M V 2022, ' A phenome-wide bidirectional Mendelian randomization analysis of atrial fibrillation ', International Journal of Epidemiology, vol. 51, no. 4, dyac041, pp. 1153-1166 . https://doi.org/10.1093/ije/dyac041 |
| Popis: |
Background The prevalence of atrial fibrillation (AF) is increasing with an aging worldwide population, yet a comprehensive understanding of its causes and consequences remains limited. We aim to assess the causes and consequences of AF via a bidirectional Mendelian randomization (MR) analysis. Methods We used publicly available genome-wide association study (GWAS) summary data, centralized and harmonized by an open GWAS database. We assessed the genetically predicted effects of 5048 exposures on risk of AF, and the genetically predicted effects of genetic liability to AF, on 10 308 outcomes via two-sample MR analysis. Multivariable MR analysis was further conducted to explore the comparative roles of identified risk factors. Results MR analysis suggested that 55 out of 5048 exposure traits, including four proteins, play a causal role in AF (P Conclusions Our results suggest body mass index, height, systolic blood pressure and genetic liability to coronary artery disease are independent causal risk factors for AF. Several proteins, including DUSP13, IL-6R and TNFSF12, may have therapeutic potential for AF. |
