SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking
| Autor: | Laura A Shaw, Margaret D. Myers, Leonard L. Dragone, Arthur Weiss |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
T-Lymphocytes
Immunology B-cell receptor Proto-Oncogene Proteins pp60(c-src) Regulator chemical and pharmacologic phenomena Immune receptor Biology Immunoreceptor tyrosine-based activation motif Immunology and Allergy Animals Humans Proto-Oncogene Proteins c-cbl Adaptor Proteins Signal Transducing B-Lymphocytes T-cell receptor Ubiquitination Signal transducing adaptor protein hemic and immune systems Cell Differentiation Cell biology Receptors Antigen Phosphorylation Signal transduction Signal Transduction |
| Zdroj: | Immunological reviews. 232(1) |
| ISSN: | 1600-065X |
| Popis: | Src-like adapter proteins (SLAP and SLAP-2) constitute a family of proteins that are expressed in a variety of cell types but are studied most extensively in lymphocytes. They have been shown to associate with proximal components of the T-cell receptor (TCR) and B-cell receptor (BCR) signaling complexes. An interaction of SLAP with c-Cbl leads to the ubiquitination and degradation of phosphorylated components of the TCR- and BCR-signaling complexes. The absence of this process in immature SLAP-deficient T and B cells leads to increased immunoreceptor levels due to decreased intracellular retention and degradation. We propose a model in which SLAP-dependent regulation of immunoreceptor levels allows for finer control of immunoreceptor signaling. Thus, SLAP functions to dampen immunoreceptor signaling, thereby influencing lymphocyte development and repertoire selection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|