High Preventive Effect of G2-S16 Anionic Carbosilane Dendrimer against Sexually Transmitted HSV-2 Infection
| Autor: | Maria Angeles Muñoz-Fernández, Ignacio Rodriguez-Izquierdo, Samanta Gasco |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Alkanesulfonates
Dendrimers Administration Topical Herpesvirus 2 Human Pharmaceutical Science Review 02 engineering and technology Pharmacology Analytical Chemistry lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry In vivo Microbicide Dendrimer Drug Discovery Animals Humans Medicine Organosilicon Compounds Physical and Theoretical Chemistry 030304 developmental biology Clinical Trials as Topic 0303 health sciences Herpes Genitalis business.industry Organic Chemistry HSV-2 021001 nanoscience & nanotechnology in vitro and in vivo studies G2-S16 dendrimer Topical microbicides Treatment Outcome Chemistry (miscellaneous) Vaginal microbiome Molecular Medicine 0210 nano-technology business microbicide |
| Zdroj: | Molecules Molecules, Vol 25, Iss 2965, p 2965 (2020) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25132965 |
| Popis: | Anionic carbosilane dendrimers such as G2-S16 are very effective in preventing HSV-2 infection both in vitro and in vivo. We present the main achievements obtained for the G2-S16 dendrimer in vivo, especially related to its efficacy against HSV-2 infection. Moreover, we discuss the mechanisms by which the G2-S16 dendrimer applied vaginally as a topical microbicide has been demonstrated to be safe and harmless for the vaginal microbiome balance, as both conditions present an essential step that has to be overcome during microbicide development. This review points to the marked protective effect of the G2-S16 dendrimer against sexually transmitted HSV-2 infection, supporting its role as a possible microbicide against HSV-2 infection. |
| Databáze: | OpenAIRE |
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