Cardiac and Pulmonary Effects of Alpha Tumor Necrosis Factor Administered by Isolation Perfusion
| Autor: | Maurilia Rizzi, Mario Santinami, Gaetano Mazzola, Renato Manzi, M. Galimberti, Fabrizio Villani, Italo Stifani |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Isolation perfusion Skin Neoplasms Dopamine medicine.medical_treatment Antineoplastic Agents 030218 nuclear medicine & medical imaging Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Respiratory system Lung Melanoma Aged Mechanical ventilation Leg Tumor Necrosis Factor-alpha business.industry Soft tissue sarcoma Extracorporeal circulation Hemodynamics Heart Sarcoma Syndrome General Medicine Middle Aged medicine.disease Shock Septic Respiratory Function Tests medicine.anatomical_structure Oncology Chemotherapy Cancer Regional Perfusion 030220 oncology & carcinogenesis Anesthesia Shock (circulatory) Heart Function Tests Arm Cardiology Female medicine.symptom business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089169508100309 |
| Popis: | Aims We studied cardiac and pulmunaty function in 22 patients affected by in transit metastases from cutaneous melanoma and metastases from soft tissue sarcoma of the limbs and treated with isolation perfusion in extracorporeal circulation with rTNF alpha at doses ranging from 0.5 to 4 mg/m2 in mild hyperthermia. Patients and methods All patients experienced a septic-like shock syndrome of variable severity: this feature lasted from 24 to 72 h and was controlled by the infusion of dopamine. Seventeen patients suffered from respiratory insufficiency, which required assisted ventilation (7 cases mechanical ventilation for 1 day, 8 cases for 2 days, and 2 cases synchronized intermittent mandatory ventilation). Results Spirometrie parameters recorded 7-15 days after treatment did not change from baseline values. In contrast, lung transfer factor for carbon monoxide significantly declined in a dose dependent fashion. Conclusions Our data confirm that rTNF alpha administered by isolation perfusion technique induces systemic cardiovascular and pulmonary side effects. Further studies are required to better define time course and reversibility of impaired pulmunary function. |
| Databáze: | OpenAIRE |
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