Antigens of subcellular fractions of Trypanosoma cruzi. III. Humoral immune response and histopathology of immunized mice
| Autor: | Humberto Golfera, Alejandro M. Katzin, Stella M. González Cappa, Elsa L. Segura, Adriana Bronzina, Gladys J.W. de Martini |
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| Rok vydání: | 1980 |
| Předmět: |
Male
Trypanosoma cruzi Microbiology Mice Immune system Antigen Animals Chagas Disease Antigens Direct fluorescent antibody biology Muscles biology.organism_classification Virology In vitro Lytic cycle Flagella Humoral immunity Antibody Formation biology.protein Parasitology Immunization Antibody Spleen Subcellular Fractions |
| Zdroj: | The Journal of protozoology. 27(4) |
| ISSN: | 0022-3921 |
| Popis: | SYNOPSIS. The relation of humoral antibody response to protection was evaluated in mice immunized with whole homogenates of Trypanosoma cruzi or with its flagellar fraction by direct agglutination and indirect fluorescent antibody test as well as by lytic and neutralizing activity against blood trypomastigotes. The results indicated that lytic antibodies were not implicated directly in protection against these trypanosomes. It was evident from histopathologic examination that the higher the degree of protection achieved, the lower the tissue damage observed in the challenged mice. Serum-neutralizing activity was highest in the groups protected most effectively. |
| Databáze: | OpenAIRE |
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