Essential Oil Content of the Rhizome of Curcuma purpurascens Bl. (Temu Tis) and Its Antiproliferative Effect on Selected Human Carcinoma Cell Lines
| Autor: | Sri Nurestri Abd Malek, Guan-Serm Lee, Omer Abdalla Ahmed Hamdi, Khalijah Awang, Sok Lai Hong, Nurfina Aznam Nugroho, Syarifah Nur Syed Abdul Rahman |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Article Subject
lcsh:Medicine Germacrone lcsh:Technology General Biochemistry Genetics and Molecular Biology law.invention chemistry.chemical_compound Sesquiterpenes Germacrane Curcuma law Botany Oils Volatile Humans lcsh:Science Cytotoxicity IC50 Essential oil General Environmental Science Cell Proliferation biology Traditional medicine lcsh:T Chemistry Cell growth Plant Extracts lcsh:R General Medicine biology.organism_classification Cytostatic Agents HCT116 Cells Rhizome MCF-7 Cells lcsh:Q Zingiberaceae HT29 Cells Research Article |
| Zdroj: | The Scientific World Journal The Scientific World Journal, Vol 2014 (2014) |
| ISSN: | 1537-744X 2356-6140 |
| Popis: | Curcuma purpurascensBl., belonging to the Zingiberaceae family, is known astemu tisin Yogyakarta, Indonesia. In this study, the hydrodistilled dried ground rhizome oil was investigated for its chemical content and antiproliferative activity against selected human carcinoma cell lines (MCF7, Ca Ski, A549, HT29, and HCT116) and a normal human lung fibroblast cell line (MRC5). Results from GC-MS and GC-FID analysis of the rhizome oil oftemu tisshowed turmerone as the major component, followed by germacrone,ar-turmerone, germacrene-B, and curlone. The rhizome oil oftemu tisexhibited strong cytotoxicity against HT29 cells (IC50value of 4.9 ± 0.4 μg/mL), weak cytotoxicity against A549, Ca Ski, and HCT116 cells (with IC50values of 46.3 ± 0.7, 32.5 ± 1.1, and 35.0 ± 0.3 μg/mL, resp.), and no inhibitory effect against MCF7 cells. It exhibited mild cytotoxicity against a noncancerous human lung fibroblast cell line (MRC5), with an IC50value of 25.2 ± 2.7 μg/mL. This is the first report on the chemical composition of this rhizome’s oil and its selective antiproliferative effect on HT29. The obtained data provided a basis for further investigation of the mode of cell death. |
| Databáze: | OpenAIRE |
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