Folic acid, dietary habits, and homocysteine levels in relation to neural tube defects: A case-control study in North India
| Autor: | Ratika Samtani, Kallur Nava Saraswathy, A.K. Kalla, Gaurav Garg, Jyoti Arora, Noopur Sharma, Deepti Saksena, Roumi Deb |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Embryology Hyperhomocysteinemia Homocysteine Health Toxicology and Mutagenesis India Physiology Folic Acid Deficiency Toxicology 03 medical and health sciences chemistry.chemical_compound Folic Acid 0302 clinical medicine Infant Mortality Odds Ratio Prevalence medicine Humans Neural Tube Defects 030212 general & internal medicine Vitamin B12 Fetus Neural tube defect business.industry Diet Vegetarian Case-control study Neural tube Infant Feeding Behavior Odds ratio Middle Aged medicine.disease Diet medicine.anatomical_structure chemistry Case-Control Studies Dietary Supplements Pediatrics Perinatology and Child Health Female business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Birth Defects Research. 110:1148-1152 |
| ISSN: | 2472-1727 |
| DOI: | 10.1002/bdr2.1373 |
| Popis: | Purpose The present study attempts to understand the complex contribution of biochemical (plasma homocysteine) and nutritional parameters (dietary pattern and folate supplementation) to the neural tube defects (NTDs) affected pregnancies and controls in North Indian population. Methods Case-control study design was adopted to assess the role of folic acid, dietary habits, and homocysteine in relation to NTD births. The subjects comprised of 130 mothers of affected children (cases) and 233 mothers of healthy children (controls), who were either carrying NTD fetus or gave birth to NTD child. Results The mean homocysteine levels were elevated in cases (15.71 ± 8.35 μmol/L) as compared to controls (12.87 ± 5.95 μmol/L) but were lower among the non-vergetarians (13.55 ± 6.64 μmol/L) than the vegetarians (14.78 ± 7.93 μmol/L). Vegetarian dietary habit increased the NTD risk by 1.6 fold (95% CI = 1.0-2.7) while folic acid supplementation demonstrated a protective effect for conceptions (OR = 0.59; 95% CI = 0.3-0.9). Consumption of folic acid with non-vegetarian diet witnessed lowering of homocysteine in cases (12.88 ± 6.81 μmol/L) and in controls (11.85 ± 5.54 μmol/L), with an odds ratio depicting a 3.1 fold risk for consuming vegetarian diet without folic acid supplementation during the peri-conceptional period. Conclusion It is suggested that plasma hyperhomocysteinemia bears negative impact on child-bearing women group, of north Indian ancestry, in modulating the risk of NTDs. Efforts should be made to enhance awareness regarding folic acid and vitamin B12 (non-vegetarian diet) supplementations alongwith proper nutritional intake among women, especially those consuming vegetarian diet to control homocysteine levels in order to reduce the risk of NTDs. |
| Databáze: | OpenAIRE |
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