Plasma matrix metalloproteinase 9 as an early surrogate biomarker of advanced colorectal neoplasia
| Autor: | Juan Ortega, Eduardo Salido, Rafael Romero, Laura Ramos, Javier Triñanes, Beatriz Abrante, David Nicolás-Pérez, Alejandro Jiménez, Antonio Z. Gimeno-García, Zaida Adrián-De-Ganzo, Marta Carrillo, Inmaculada Alonso, Onofre Alarcón-Fernández, Enrique Quintero |
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| Rok vydání: | 2016 |
| Předmět: |
Adenoma
Male medicine.medical_specialty Pathology MMP2 Colorectal cancer Colonoscopy Adenocarcinoma Polymorphism Single Nucleotide Sensitivity and Specificity Gastroenterology Adenomatous Polyps 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Biomarkers Tumor medicine Humans Gelatinase Prospective Studies Aged Hepatology medicine.diagnostic_test Receiver operating characteristic business.industry Middle Aged medicine.disease Matrix Metalloproteinase 9 ROC Curve Area Under Curve 030220 oncology & carcinogenesis Disease Progression Matrix Metalloproteinase 2 Biomarker (medicine) Female 030211 gastroenterology & hepatology Colorectal Neoplasms business |
| Zdroj: | Gastroenterología y Hepatología. 39:433-441 |
| ISSN: | 0210-5705 |
| DOI: | 10.1016/j.gastrohep.2015.10.002 |
| Popis: | Matrix metalloproteinases (MMPs) are overexpressed at different stages of colorectal carcinogenesis and could serve as early surrogate biomarkers of colorectal neoplasia.To assess the utility of plasma MMP2 and MMP9 levels in the detection of advanced colorectal neoplasia and their correlation with tissue levels.We analysed blood and tissue samples from patients with non-advanced adenomas (n=25), advanced adenomas (n=25), colorectal cancer (n=25) and healthy controls (n=75). Plasma and tissue gelatinase levels were determined by Luminex XMAP technology and gelatin zymography. Receiver operating characteristic (ROC) curve analysis was used to calculate the optimum cut-off for the detection of advanced colorectal neoplasia.Plasma MMP2 levels were similar between groups whatever the type of lesion. Plasma MMP9 levels were significantly higher in patients with neoplastic lesions than in healthy controls (median 292.3ng/ml vs. 139.08ng/ml, P0.001). MMP9 levels were also higher in colorectal cancer than in non-advanced adenomas (median 314.6ng/ml vs. 274.3ng/ml, P=0.03). There was a significant correlation between plasma and tissue levels of MMP9 (r=0.5, P0.001). The plasma MMP9 cut-off range with the highest diagnostic accuracy was between 173ng/ml and 204ng/ml (AUC=0.80 [95% CI: 0.72-0.86], P0.001; sensitivity, 80-86% and specificity, 57-67%).Plasma MMP9 could be a surrogate biomarker for the early detection of advanced colorectal neoplasia, although its diagnostic performance could be increased by combination with other biomarkers. |
| Databáze: | OpenAIRE |
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