Weaving Mitochondrial DNA and Y-Chromosome Variation in the Panamanian Genetic Canvas
| Autor: | Jorge Motta, Luca Ferretti, Ana Maria Chero Osorio, Marco Rosario Capodiferro, Alessandro Raveane, Anna Olivieri, Giulia Colombo, Maria Garofalo, Nicole E. Smith-Guzmán, Ugo A. Perego, Richard G. Cooke, Tomás Mendizábal, Nicola Rambaldi Migliore, Lucia Mazzocchi, Antonio Torroni, Bethany Aram, Maribel Tribaldos, Alessandro Achilli, Stella Gagliardi, Gianluca Lombardo, Alejandro García Montón, Viola Grugni, Cristina Cereda, Ornella Semino |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Mitochondrial DNA Genotype Panama Population Black People mitochondrial DNA QH426-470 Biology phylogeography Y chromosome DNA Mitochondrial Indigenous Article Isthmus of Panama uniparental transmission indigenous American lineages and genetic history sex bias Genetics Humans education Indigenous Peoples Genetics (clinical) Africa South of the Sahara education.field_of_study Chromosomes Human Y Racial Groups Genetic Variation Gene Pool Sequence Analysis DNA Pedigree Phylogeography Evolutionary biology Genetic structure Female Sample collection |
| Zdroj: | Genes Genes 2021, 12(12), 1921 Genes; Volume 12; Issue 12; Pages: 1921 Genes, Vol 12, Iss 1921, p 1921 (2021) |
| ISSN: | 2073-4425 |
| Popis: | The Isthmus of Panama was a crossroads between North and South America during the continent's first peopling (and subsequent movements) also playing a pivotal role during European colonization and the African slave trade. Previous analyses of uniparental systems revealed significant sex biases in the genetic history of Panamanians, as testified by the high proportions of Indigenous and sub-Saharan mitochondrial DNAs (mtDNAs) and by the prevalence of Western European/northern African Y chromosomes. Those studies were conducted on the general population without considering any self-reported ethnic affiliations. Here, we compared the mtDNA and Y-chromosome lineages of a new sample collection from 431 individuals (301 males and 130 females) belonging to either the general population, mixed groups, or one of five Indigenous groups currently living in Panama. We found different proportions of paternal and maternal lineages in the Indigenous groups testifying to pre-contact demographic events and genetic inputs (some dated to Pleistocene times) that created genetic structure. Then, while the local mitochondrial gene pool was marginally involved in post-contact admixtures, the Indigenous Y chromosomes were differentially replaced, mostly by lineages of western Eurasian origin. Finally, our new estimates of the sub-Saharan contribution, on a more accurately defined general population, reduce an apparent divergence between genetic and historical data. Universidad Pablo Olavide. Departamento de Geografía, Historia y Filosofía |
| Databáze: | OpenAIRE |
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