Interferon Alfa-2A Therapy for Airway Hemangiomas
| Autor: | Laurie A. Ohlms, Gerald B. Healy, Trevor J. McGill, Dwight T. Jones |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Stridor Alpha interferon Interferon alpha-2 Hemangioma 03 medical and health sciences 0302 clinical medicine Adrenal Cortex Hormones medicine Humans Prospective Studies 030223 otorhinolaryngology Subglottis Interferon alfa business.industry Remission Induction Infant Interferon-alpha Mediastinum Neoplasms Second Primary General Medicine respiratory system Airway obstruction medicine.disease Combined Modality Therapy Magnetic Resonance Imaging Recombinant Proteins respiratory tract diseases Surgery Airway Obstruction Treatment Outcome medicine.anatomical_structure Otorhinolaryngology Head and Neck Neoplasms Child Preschool 030220 oncology & carcinogenesis Female Laser Therapy Tracheotomy medicine.symptom Tomography X-Ray Computed business Airway Follow-Up Studies medicine.drug |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 103:1-8 |
| ISSN: | 1943-572X 0003-4894 |
| Popis: | Hemangioma is a well-recognized cause of airway obstruction in the infant with stridor. Corticosteroid and laser therapy are effective in stabilizing the airway in most cases. There are, however, some extensive airway lesions that are not adequately managed by these modalities. This report describes the use of recombinant interferon alfa-2a in 15 patients with life-threatening airway hemangiomas. All patients had failed corticosteroid and/or laser therapy. Multiple upper airway sites were involved, including the base of the tongue, supraglottis, subglottis, trachea, and mediastinum. Eleven patients have completed therapy and are doing well. Four patients have resolving lesions on the drug regimen. Life-threatening airway lesions unresponsive to conventional treatment should be considered for a trial of interferon alfa-2a. |
| Databáze: | OpenAIRE |
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