Amyloid β-Protein Induces Its Own Production in Cultured Degenerating Cerebrovascular Smooth Muscle Cells
| Autor: | Carl W. Cotman, Susan M. Saporito-irwin, W E Van Nostrand, J Davis-Salinas |
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| Rok vydání: | 2002 |
| Předmět: |
chemistry.chemical_classification
Pathology medicine.medical_specialty Amyloid beta-Peptides Amyloid Amyloid β Immunoblotting Peptide Biology medicine.disease Precipitin Tests Biochemistry Muscle Smooth Vascular Peptide Fragments Cellular and Molecular Neuroscience Degenerative disease Smooth muscle chemistry Cerebrovascular Circulation Parenchyma medicine Humans Alzheimer's disease Cells Cultured Cerebrovascular pathology |
| Zdroj: | Journal of Neurochemistry. 65:931-934 |
| ISSN: | 1471-4159 0022-3042 |
| Popis: | The progression of Alzheimer's disease and related disorders involves amyloid beta-protein (A beta) deposition and pathologic changes in the parenchyma as well as cerebral blood vessels. The cerebrovascular A beta deposits in these disorders are associated with degenerating smooth muscle cells in the vessel wall, which have been shown to express the A beta precursor (A beta PP) and A beta. Here, we show that A beta 1-42, an abundant cerebrovascular form of A beta, causes cellular degeneration in cultured human cerebrovascular smooth muscle cells. This stress response is accompanied by a striking increase in the levels of cellular A beta PP and soluble A beta peptide produced in these degenerating cells. These data provide the first experimental evidence that A beta can potentially contribute to the onset and progression of the cerebrovascular pathology. The present findings suggest that this mechanism may involve a molecular cascade with a novel product-precursor relationship that results in the adverse production and subsequent accumulation of A beta. |
| Databáze: | OpenAIRE |
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