Respiratory-associated deaths in people with intellectual disabilities: a systematic review and meta-analysis
| Autor: | Craig Melville, Bhautesh Dinesh Jani, Angela Henderson, Kirsty Dunn, Fiona Barlow, Ewelina Rydzewska, Gillian S. Smith, Deborah Kinnear, Laura Hughes-Mccormack, Joseph D. Symonds, Maria Truesdale, Arlene M. McGarty |
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| Rok vydání: | 2021 |
| Předmět: |
Gerontology
Adult medicine.medical_specialty Population MEDLINE CINAHL 03 medical and health sciences respiratory infections 0302 clinical medicine Risk Factors Cause of Death Intellectual Disability Intellectual disability medicine Humans respiratory medicine (see thoracic medicine) 030212 general & internal medicine education Respiratory Medicine education.field_of_study business.industry Mortality Premature Public health public health General Medicine medicine.disease Respiration Disorders Study heterogeneity Standardized mortality ratio Meta-analysis Medicine business 030217 neurology & neurosurgery |
| Zdroj: | BMJ Open Truesdale, M, Melville, C, Barlow, F, Dunn, K, Henderson, A, Hughes-Mccormack, L A, McGarty, A, Rydzewska, E, Smith, G S, Symonds, J, Jani, B & Kinnear, D 2021, ' Respiratory-associated deaths in people with intellectual disabilities : A systematic review and meta-analysis ', BMJ Open, vol. 11, no. 7, e043658 . https://doi.org/10.1136/bmjopen-2020-043658 BMJ Open, Vol 11, Iss 7 (2021) BASE-Bielefeld Academic Search Engine |
| ISSN: | 2044-6055 |
| Popis: | ObjectiveTo review and synthesise evidence on rates of respiratory-associated deaths and associated risk factors in the intellectual disability population.DesignSystematic review and meta-analysis.Data sourcesEmbase, CINAHL, ISI Web of Science (all databases including Medline) and PsychINFO were searched for studies published between 1st January 1985 and 27th April 2020 and examined study and outcome quality. Reference lists and Google Scholar were also hand searched.ResultsWe identified 2295 studies, 17 were included in the narrative synthesis and 10 studies (11 cohorts) in the meta-analysis. Data from 90 302 people with intellectual disabilities and 13 808 deaths from all causes in people with intellectual disabilities were extracted. Significantly higher rates of respiratory-associated deaths were found among people with intellectual disabilities (standardised mortality ratio(SMR): 10.86 (95% CI: 5.32 to 22.18, p2=99.0%.ConclusionPremature deaths due to respiratory disorders are potentially avoidable with improved public health initiatives and equitable access to quality healthcare. Further research should focus on developing prognostic guidance and validated tools for clinical practice to mitigate risks of respiratory-associated deaths.PROSPERO registration numberCRD42020180479. |
| Databáze: | OpenAIRE |
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