Antimicrobial and anti-lipase activity of quercetin and its C2-C16 3-O-acyl-esters
| Autor: | Gabriela Mazzanti, Serena Falcocchio, Eleonora Grippa, Lucia Battinelli, Maria Teresa Gatto, Daniela Lambusta, Giovanni Nicolosi, Luciano Saso |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Anti-HIV Agents
Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science CANDIDA-RUGOSA LIPASE PHENOLIC-COMPOUNDS FLAVONOIDS ACNES medicine.disease_cause Biochemistry Microbiology Inhibitory Concentration 50 Shigella flexneri Anti-Infective Agents Drug Discovery medicine Humans Shigella sonnei Enzyme Inhibitors Lipase Candida albicans Molecular Biology Candida Bacteria biology Candida glabrata Chemistry Organic Chemistry Esters biology.organism_classification Anti-Bacterial Agents Candida rugosa Staphylococcus aureus HIV-1 biology.protein Listeria Molecular Medicine Quercetin |
| Zdroj: | Bioorganic & medicinal chemistry info:cnr-pdr/source/autori:Gatto M. T., Falcocchio S., Grippa E., Mazzanti G., Battinelli L., Nicolosi G., Lambusta D., Saso L./titolo:Antimicrobial and Anti-Lipase Activity of Quercetin and Its C2-C16 3-O-Acyl-Esters/doi:/rivista:Bioorganic & medicinal chemistry (Print)/anno:2002/pagina_da:269/pagina_a:272/intervallo_pagine:269–272/volume:10 Bioorganic & medicinal chemistry (Online) 10 (2002): 269–272. info:cnr-pdr/source/autori:Maria Teresa Gatto,a Serena Falcocchio,a Eleonora Grippa,a Gabriela Mazzanti,a Lucia Battinelli,a Giovanni Nicolosi,b Daniela Lambusta b and Luciano Saso a,*/titolo:Antimicrobial and Anti-Lipase Activity of Quercetin and Its C2-C16 3-O-Acyl-Esters/doi:/rivista:Bioorganic & medicinal chemistry (Online)/anno:2002/pagina_da:269/pagina_a:272/intervallo_pagine:269–272/volume:10 |
| Popis: | Neither quercetin (Q), nor 3-O-acylquercetines, up to 100 microg/mL, had any significant activity on selected gram-positive strains (Staphylococcus aureus, Bacillus subtilis, Listeria ivanovi, Listeria monocytogenes, Listeria serligeri), gram-negative strains (Escherichia coli, Shigella flexneri, Shigella sonnei, Salmonella enteritidis, Salmonella tiphymurium) and yeasts (Candida albicans and Candida glabrata). In addition, we confirmed the known anti-HIV activity of Q (80% inhibition at 40 microM), which might depend on the free hydroxyl in the C-3 position, as suggested by the lack of activity of the 3-O-acylquercetines. Finally, we described an interesting inhibitory activity on Candida rugosa lipase by Q (IC(16)=10(-4) M) and its esters (3-O-acylquercetines) which, in vivo, could play an important role against lipase producing microorganisms. In particular, 3-O-acyl-quercetines, being more active (IC(16)=10(-4)-10(-6) M) and more lipophilic, could be more effective than Q when applied to the skin or mucosae, and deserve to be studied further. |
| Databáze: | OpenAIRE |
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