Up-Regulation of the Human Serum and Glucocorticoid-Dependent Kinase 1 in Glomerulonephritis
| Autor: | Martina Sauter, Bjoern Friedrich, Florian Lang, Ralph Witzgall, Wilhelm Kriz, Teut Risler, Karin Klingel, Reinhard Kandolf, Gerhard A. Müller, Hermann Josef Gröne, S. Wärntges |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty 030232 urology & nephrology In situ hybridization Protein Serine-Threonine Kinases Biology Kidney Immediate-Early Proteins 03 medical and health sciences Glomerulonephritis 0302 clinical medicine Downregulation and upregulation Internal medicine medicine Transcriptional regulation Humans Tissue Distribution RNA Messenger In Situ Hybridization Aged 030304 developmental biology 0303 health sciences Kinase Nuclear Proteins General Medicine Middle Aged medicine.disease Up-Regulation Endocrinology Nephrology Transforming growth factor beta 3 SGK1 Female Cardiology and Cardiovascular Medicine Glucocorticoid medicine.drug |
| Zdroj: | Kidney and Blood Pressure Research. 25:303-307 |
| ISSN: | 1423-0143 1420-4096 |
| Popis: | Glomerulonephritis is paralleled by excessive formation of transforming growth factor-beta (TGF-β), which participates in the pathophysiology of the disease. Recently, a novel downstream target of TGF-β has been identified, i.e. the human serum and glucocorticoid-dependent kinase 1 (hSGK1), a serine/threonine kinase participating in the regulation of Na+ transport. The present study was performed to elucidate transcriptional regulation of hSGK1 in glomerulonephritis. To this end, in situ hybridization was performed in biopsies from patients with clinical diagnosis of glomerulonephritis. hSGK1 transcript levels were moderately enhanced in 5 out of 9 patients and strongly enhanced in 4 out of 9 patients. Distal nephron epithelial cell hSGK1 transcript levels were low or absent in 7 of the 9 patients but markedly enhanced in 2 of the 9 patients. In conclusion, glomerulonephritis leads to glomerular and in some cases to epithelial up-regulation of hSGK1 transcription. |
| Databáze: | OpenAIRE |
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