Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain
| Autor: | O. Sleglova, Jiří Vencovský, Karel Pavelka, Olga Růžičková, Ladislav Šenolt, Tereza Kropáčková |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Sports medicine Hand Joints Visual analogue scale Down-Regulation Enzyme-Linked Immunosorbent Assay Disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Rheumatology Predictive Value of Tests Erosive osteoarthritis Internal medicine Osteoarthritis Hand osteoarthritis Epidemiology medicine Humans Orthopedics and Sports Medicine Aged Pain Measurement Ultrasonography 030203 arthritis & rheumatology Clusterin biology business.industry Middle Aged Arthralgia Cross-Sectional Studies 030104 developmental biology Case-Control Studies Orthopedic surgery biology.protein Female lcsh:RC925-935 business Biomarkers Research Article |
| Zdroj: | BMC Musculoskeletal Disorders, Vol 19, Iss 1, Pp 1-6 (2018) BMC Musculoskeletal Disorders |
| ISSN: | 1471-2474 |
| DOI: | 10.1186/s12891-018-2179-3 |
| Popis: | Background The aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non-erosive disease, and to examine the association of CLU levels with clinical and laboratory parameters. Methods A total of 135 patients with hand OA (81 with erosive and 54 with non-erosive disease) and 53 healthy individuals were included in this study. All patients underwent clinical and hand joint ultrasound examination. The Australian/Canadian (AUSCAN) hand osteoarthritis index, algofunctional index and a visual analogue scale (VAS) for the measurement of pain were assessed. Serum levels of CLU were measured by an enzyme-linked immunosorbent assay (ELISA). Results Serum levels of CLU were significantly lower in patients with hand OA than in control subjects (p |
| Databáze: | OpenAIRE |
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