Hypoxia-Responsive Lipid–Polymer Nanoparticle-Combined Imaging-Guided Surgery and Multitherapy Strategies for Glioma

Autor: Rutong Yu, Zhen Wang, Jun Lu, Zongren Zhao, Yuhan Han, Liang Zhao, Konduru Naveena, Hongmei Liu, Gang Zhao, Long Zhang, Lei Hua, Haoyue Xu
Rok vydání: 2020
Předmět:
Indocyanine Green
medicine.medical_specialty
Materials science
genetic structures
Cell Survival
Infrared Rays
Photothermal Therapy
Polymers
medicine.medical_treatment
Transplantation
Heterologous
Photodynamic therapy
02 engineering and technology
030226 pharmacology & pharmacy
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cell Line
Tumor
Glioma
polycyclic compounds
medicine
Animals
Humans
General Materials Science
Doxorubicin
Mice
Inbred ICR
Chemotherapy
Antibiotics
Antineoplastic
Photosensitizing Agents
Nitroimidazole
Hypoxia (medical)
Photothermal therapy
021001 nanoscience & nanotechnology
medicine.disease
Lipids
eye diseases
Surgery
Photochemotherapy
chemistry
Nanoparticles
Female
medicine.symptom
Peptides
0210 nano-technology
Indocyanine green
medicine.drug
Zdroj: ACS Applied Materials & Interfaces. 12:52319-52328
ISSN: 1944-8252
1944-8244
DOI: 10.1021/acsami.0c12971
Popis: Glioma is the most prevalent type of malignant brain tumor and is usually very aggressive. Because of the high invasiveness and aggressive proliferative growth of glioma, it is difficult to resect completely or cure with surgery. Residual glioma cells are a primary cause of postoperative recurrence. Herein, we describe a hypoxia-responsive lipid polymer nanoparticle (LN) for fluorescence-guided surgery, chemotherapy, photodynamic therapy (PDT), and photothermal therapy (PTT) combination multitherapy strategies targeting glioma. The hypoxia-responsive LN [LN (DOX + ICG)] contains a hypoxia-responsive component poly(nitroimidazole)25 [P-(Nis)25], the glioma-targeting peptide angiopep-2 (A2), indocyanine green (ICG), and doxorubicin (DOX). LN (DOX + ICG) comprises four distinct functional components: (1) A2: A2 modified nanoparticles effectively target gliomas, enhancing drug concentration in gliomas; (2) P-(Nis)25: (i) the hydrophobic component of LN (DOX + ICG) with hypoxia responsive ability to encapsulate DOX and ICG; (ii) allows rapid release of DOX from LN (DOX + ICG) after 808 nm laser irradiation; (3) ICG: (i) ICG allows imaging-guided surgery, combining PDT and PTT therapies; (ii) upon irradiation with an 808 nm laser, ICG creates a hypoxic environment; (4) DOX inhibits glioma growth. This work demonstrates that LN (DOX + ICG) might provide a novel clinical approach to preventing post-surgical recurrence of glioma.
Databáze: OpenAIRE
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