Transsynaptic Coordination of the Formation of Morphofunctional Contacts between the Brain and the Neurotransplant: an Ulrastructural Study
| Autor: | E. A. Mugantseva, Z. N. Zhuravleva, G. I. Zhuravlev |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Cell signaling Cell Communication Biology Synaptic vesicle General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Fetal Tissue Transplantation medicine Animals Brain Tissue Transplantation Active zone Rats Wistar Neurotransmitter Neurons Neurotransmitter Agents Neocortex Secretory Vesicles Vesicle Dentate gyrus Graft Survival Somatosensory Cortex General Medicine Rats medicine.anatomical_structure chemistry Dentate Gyrus Mossy Fibers Hippocampal Microscopy Electron Scanning Fascia dentata Synaptic Vesicles Neuroscience |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 160:91-95 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We studied the role of neurotransmitter signaling mediated by synaptic vesicles in the formation of aberrant functional connections between fascia dentata grafts and the somatosensory neocortex in adult rats. Quantitative analysis of the different populations of synaptic vesicles in the ectopic giant axonal endings of granular neurons was performed and the results were compared with the normal. Two pools of small clear vesicles (rapidly releasable pool and pool of reserve vesicles circulating in the active zone) and one pool of large dense-core vesicles were analyzed. Significant differences from the control suggest that synaptic integration of the transplants into the recipient brain is coordinated by transsynaptic signaling and mediated by different populations of synaptic vesicles. |
| Databáze: | OpenAIRE |
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