Mammalian‐Cell‐Driven Polymerisation of Pyrrole
| Autor: | Akhil Jain, Harry G. Sherman, Jacqueline M. Hicks, Cameron Alexander, Jeremy J. Titman, Frankie J. Rawson, Snow Stolnik |
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| Rok vydání: | 2019 |
| Předmět: |
010402 general chemistry
Polypyrrole 01 natural sciences Biochemistry Redox Polymerization chemistry.chemical_compound medicine Animals Humans Pyrroles Transcellular Molecular Biology Cell damage Conductive polymer 010405 organic chemistry Organic Chemistry medicine.disease 0104 chemical sciences Membrane chemistry Biophysics Molecular Medicine Ferricyanide Ferrocyanide K562 Cells |
| Zdroj: | ChemBioChem. 20:1008-1013 |
| ISSN: | 1439-7633 1439-4227 |
| DOI: | 10.1002/cbic.201800630 |
| Popis: | A model cancer cell line was used to initiate polymerisation of pyrrole to form the conducting material polypyrrole. The polymerisation was shown to occur through the action of cytosolic exudates rather than that of the membrane redox sites that normally control the oxidation state of iron as ferricyanide or ferrocyanide. The data demonstrate for the first time that mammalian cells can be used to initiate synthesis of conducting polymers and suggest a possible route to detection of cell damage and/or transcellular processes through in situ and amplifiable signal generation. |
| Databáze: | OpenAIRE |
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