Serum glypican4 and glycosylphosphatidylinositol-specific phospholipase D levels are associated with adipose tissue insulin resistance in obese subjects with different glucose metabolism status
| Autor: | Hongbo Yang, Hui Pan, Lin jie Wang, Feng ying Gong, Kun Zhang, Huijuan Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male China medicine.medical_specialty Endocrinology Diabetes and Metabolism Adipose tissue Adipokine 030209 endocrinology & metabolism Carbohydrate metabolism Cohort Studies Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Glypicans Internal medicine Glucose Intolerance Phospholipase D medicine Hyperinsulinemia Humans Insulin Obesity Adiponectin business.industry Type 2 Diabetes Mellitus Glucose Tolerance Test Middle Aged medicine.disease Adipose Tissue Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Female Insulin Resistance business Biomarkers |
| Zdroj: | Journal of Endocrinological Investigation. 44:781-790 |
| ISSN: | 1720-8386 |
| DOI: | 10.1007/s40618-020-01372-9 |
| Popis: | Glypican4 (GPC4) is a novel adipokine associated with obesity and insulin resistance. GPC4 was cleaved by the glycosylphosphatidylinositol-specific phospholipase D (GPLD1) in an anchored site of the glycosylphosphatidylinositol, and then was released into the extracellular environment. Herein, we investigated the changes of serum GPC4 and GPLD1 levels in obese subjects with different glucose metabolism status and their relationship with adipose tissue insulin resistance index (Adipo-IR) in Chinese north populations. A total of 221 obese subjects and 37 normal controls (NC) were recruited in this study. Obese subjects were divided into normal insulin (NI) group, hyperinsulinemia (HI) group, impaired glucose tolerance (IGT) group, and type 2 diabetes mellitus (DM) group. Serum GPC4, GPLD1, and adiponectin were determined by commercially available ELISA kits. Serum GPC4 levels in the HI, IGT, and DM groups were significantly higher than those in the NC and NI groups (2.27 ± 0.58 ng/mL, 2.21 ± 0.60 ng/mL, 2.49 ± 0.67 ng/mL vs. 1.70 ± 0.33 ng/mL, 1.93 ± 0.34 ng/mL, P |
| Databáze: | OpenAIRE |
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