Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis
| Autor: | Ronen Polsky, David R. Wheeler, Xiaoyin Xiao, Susan M. Brozik, Philip R. Miller, Roger J. Narayan, Dulce C. Arango, Shelby A. Skoog, Joseph Wang, DeAnna M. Lopez, Thayne L. Edwards |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Biosensing Techniques
engineering.material Article Analytical Chemistry Glucose Oxidase chemistry.chemical_compound Coated Materials Biocompatible Coating Cell Adhesion medicine Humans Glucose oxidase Lactic Acid Exercise Acidosis biology Chemistry Macrophages Metabolic acidosis Electrochemical Techniques Adhesion Hydrogen-Ion Concentration medicine.disease Carbon Amperometry Lactic acid Microelectrode Glucose Biochemistry Needles engineering biology.protein Biophysics medicine.symptom Microelectrodes |
| Zdroj: | Talanta. 88:739-742 |
| ISSN: | 0039-9140 |
| Popis: | The development of a microneedle-based biosensor array for multiplexed in situ detection of exercise-induced metabolic acidosis, tumor microenvironment, and other variations in tissue chemistry is described. Simultaneous and selective amperometric detection of pH, glucose, and lactate over a range of physiologically relevant concentrations in complex media is demonstrated. Furthermore, materials modified with a cell-resistant (Lipidure®) coating were shown to inhibit macrophage adhesion; no signs of coating delamination were noted over a 48-h period. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect