Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis
| Autor: | Duane D. Miller, Dong Jin Hwang, Souvik Banerjee, Wei Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
tubulin dynamics Angiogenesis Pharmaceutical Science Neovascularization Physiologic Angiogenesis Inhibitors Antineoplastic Agents Review macromolecular substances Pharmacology Biology tubulin inhibitors Analytical Chemistry lcsh:QD241-441 03 medical and health sciences angiogenesis 0302 clinical medicine Drug Delivery Systems β-tubulin isotypes and drug resistance lcsh:Organic chemistry Microtubule Tubulin multidrug resistance Neoplasms Drug Discovery Animals Humans antimitotic Physical and Theoretical Chemistry Cytotoxicity Drug Carriers Binding Sites Neovascularization Pathologic nanoparticle formulations Organic Chemistry Tubulin Modulators 3. Good health Multiple drug resistance 030104 developmental biology Chemistry (miscellaneous) Cell culture 030220 oncology & carcinogenesis Drug delivery Toxicity Molecular Medicine Nanoparticles Tumor necrosis factor alpha vascular disrupting agent Protein Binding |
| Zdroj: | Molecules, Vol 21, Iss 11, p 1468 (2016) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Extensive research over the last decade has resulted in a number of highly potent tubulin polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or microtubule destabilizing agents (MDAs). These inhibitors have potent cytotoxicity against a broad spectrum of human tumor cell lines. In addition to cytotoxicity, a number of these tubulin inhibitors have exhibited abilities to inhibit formation of new blood vessels as well as disrupt existing blood vessels. Tubulin inhibitors as a vascular disrupting agents (VDAs), mainly from the MDA family, induce rapid tumor vessel occlusion and massive tumor necrosis. Thus, tubulin inhibitors have become increasingly popular in the field of tumor vasculature. However, their pharmaceutical application is halted by a number of limitations including poor solubility and toxicity. Thus, recently, there has been considerable interests in the nanoparticle drug delivery of tubulin inhibitors to circumvent those limitations. This article reviews recent advances in nanoparticle based drug delivery for tubulin inhibitors as well as their tumor vasculature disruption properties. |
| Databáze: | OpenAIRE |
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