Autoimmune hypophysitis secondary to therapy with immune checkpoint inhibitors: Four cases describing the clinical heterogeneity of central endocrine dysfunction
| Autor: | Bjoern G Volkmer, Frank Schuppert, Amelie Hartmann, Andreas Wittig, Rainer Rompel, Maria Paparoupa |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Immune checkpoint inhibitors Ipilimumab Bioinformatics 03 medical and health sciences 0302 clinical medicine Clinical heterogeneity medicine Endocrine system Humans Pharmacology (medical) Autoimmune Hypophysitis Adverse effect Carcinoma Renal Cell Immune Checkpoint Inhibitors Melanoma Aged business.industry Middle Aged medicine.disease Kidney Neoplasms Nivolumab Oncology 030220 oncology & carcinogenesis Autoimmune hypophysitis 030211 gastroenterology & hepatology Female business medicine.drug |
| Zdroj: | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 26(7) |
| ISSN: | 1477-092X |
| Popis: | Introduction Immune checkpoint inhibitors are becoming increasingly important in oncology. Immune-related adverse events, including autoimmune hypophysitis, have been reported before. Case report We present a case series of three males and one female, suffering from either malignant melanoma or renal cell carcinoma, who developed hypophysitis under Nivolumab and/or Ipilimumab. A wide range of clinical manifestations from asymptomatic hypophysitis, headache, general weakness, loss of appetite, visual field impairment, and confusion to acute life-threatening Addison crisis was observed. Management and outcome: All patients received corticosteroids. Immune checkpoint inhibitors were discontinued in three cases until resolution of symptoms. Discussion The objective of our report is to raise the awareness of physicians, regarding this rare clinical entity, which may become life-threatening, if not promptly recognized and properly treated. |
| Databáze: | OpenAIRE |
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