Soluble HLA-I in rheumatic diseases
Autor: | Frank B. Gelder, Vicky C. Hall, John C. McDonald, Robert E. Wolf, Irena Adamashvili, Patricia A. Fraser |
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Rok vydání: | 1998 |
Předmět: |
West Indies
Immunology Black People Disease Human leukocyte antigen Polymyositis Georgia (Republic) Scleroderma White People Arthritis Rheumatoid HLA Antigens Rheumatic Diseases medicine Immunology and Allergy Humans Lupus Erythematosus Systemic skin and connective tissue diseases Myositis Scleroderma Systemic business.industry Histocompatibility Antigens Class I General Medicine Dermatomyositis medicine.disease Louisiana Pathophysiology Solubility Rheumatoid arthritis business |
Zdroj: | Human immunology. 59(10) |
ISSN: | 0198-8859 |
Popis: | Objective: To study serum levels of Class I soluble HLA (sHLA-I) in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), polymyositis or dermatomyositis (PM/DM) or scleroderma and to assess the possible influence of ethnic factors on concentration in each disease group. Methods: Solid-phase enzyme linked immunoassay was used to measure sHLA-I in the serum of 385 patients with varied ethnic backgrounds (American-Caucasians, African-Americans, Georgian-Caucasians) with rheumatic diseases. Studies on patients were compared to similar measurements of 189 healthy individuals. Results: Mean sHLA-I levels were significantly higher in patients with SLE than those observed in healthy individuals or other rheumatic diseases. Highest concentrations were present in Georgian-Caucasian patients with SLE. American-Caucasian patients with RA or scleroderma had higher sHLA-I levels than normal Caucasian individuals. The majority of patients with PM/DM in all ethnic subgroups were low secretors of sHLA-I. Conclusion: Mechanisms underlying the secretion of sHLA-I appear to differ among the rheumatic diseases studied and various ethnic groups. These genetic differences in sHLA-I secretion could be associated with ethnic and pathophysiologic differences among these rheumatic diseases. |
Databáze: | OpenAIRE |
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